Phenotypes Associated with This Genotype

Genotype
MGI:2662360

• Allelic Composition: Tg(ACTB-Mgat3)2Nta/0
• Genetic Background: involves: C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal definitive hematopoiesis ( J:80227 )

• delayed hematopoietic recovery following bone marrow transplantation

• number of CFU-mix (hemoprogenitors), CFU-GM (myeloid progenitors) and BFU-E (erythroid precursors) are decreased in bone marrow and spleen

• bone marrow stromal cells show decreased non-adherent cell production in culture, indicating dysfunction of stroma-dependent hemopoiesis

decreased erythroid progenitor cell number ( J:80227 )

decreased erythrocyte cell number ( J:80227 )

• in peripheral blood

decreased hemoglobin content ( J:80227 )

thrombocytopenia ( J:80227 )

• in peripheral blood

decreased leukocyte cell number ( J:80227 )

• in peripheral blood

decreased neutrophil cell number ( J:80227 )

decreased lymphocyte cell number ( J:80227 )

pancytopenia ( J:80227 )

• peripheral blood hematology indicates pancytopenia

• pancytopenia following bone marrow transplantation

spleen atrophy ( J:80227 )

decreased spleen B cell follicle number ( J:80227 )

• decrease in follicle numbers and in follicle diameter

immune system

decreased leukocyte cell number ( J:80227 )

• in peripheral blood

decreased neutrophil cell number ( J:80227 )

decreased lymphocyte cell number ( J:80227 )

spleen atrophy ( J:80227 )

decreased spleen B cell follicle number ( J:80227 )

• decrease in follicle numbers and in follicle diameter

skeleton

abnormal bone marrow morphology ( J:80227 )

• hypoplastic bone marrow

• bone marrow stromal cells show decreased non-adherent cell production in culture, indicating dysfunction of stroma-dependent hemopoiesis