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Phenotypes Associated with This Genotype
Genotype
MGI:2662270
Allelic
Composition
Slc27a4wrfr/Slc27a4wrfr
Genetic
Background
involves: 129 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc27a4wrfr mutation (0 available); any Slc27a4 mutation (12 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Histological analysis of the Slc27a4wrfr/Slc27a4wrfr mouse

mortality/aging
• mice died several hours after birth

behavior/neurological
• mice failed to suckle
• body movements were extremely limited in mice

digestive/alimentary system
• herniated intestines observed in 10 % of mutant mice

respiratory system

integument
• hair growth is impaired; compared to controls, hair growth was sparse in skin taken from E18.5 mice and grafted onto nude
• few developing hair follicles
• skin appeared abnormally shiny at birth
• the skin mutant mice lacked the wrinkled appearance associated with normal perinatal mice
• in newborns, epidermis was 3 times thicker than littermate controls

Mouse Models of Human Disease
OMIM ID Ref(s)
Restrictive Dermopathy, Lethal 275210 J:83282


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/19/2016
MGI 6.03
The Jackson Laboratory