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Phenotypes Associated with This Genotype
Genotype
MGI:2662258
Allelic
Composition		 Cd80tm1Shr/Cd80tm1Shr
Genetic
Background		 involves: 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd80tm1Shr mutation (12 available); any Cd80 mutation (42 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased B cell proliferation ( J:74662 )
• B cells stimulated with LPS and dextran show a mixed lymphocyte response that is reduced by 70% compared to wild-type
abnormal immunoglobulin level ( J:39089 )
• production of IgG1, IgG2a and IgM is reduced to 25-50% of wild-type after immunization with trinitrophenyl conjugates of keyhole limpet hemocyanin or ovalbumin

hematopoietic system
decreased B cell proliferation ( J:74662 )
• B cells stimulated with LPS and dextran show a mixed lymphocyte response that is reduced by 70% compared to wild-type
abnormal immunoglobulin level ( J:39089 )
• production of IgG1, IgG2a and IgM is reduced to 25-50% of wild-type after immunization with trinitrophenyl conjugates of keyhole limpet hemocyanin or ovalbumin

cellular
decreased B cell proliferation ( J:74662 )
• B cells stimulated with LPS and dextran show a mixed lymphocyte response that is reduced by 70% compared to wild-type

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory