Phenotypes Associated with This Genotype

Genotype
MGI:2662148

• Allelic Composition: Cd7^tm1Bfh/Cd7^tm1Bfh
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:48758 )

N • homozygotes are viable and do not exhibit a SCID syndrome

N • thymic cortical and medullary areas and B cell follicles and germinal centers in lymph node and spleen are normal

N • at 3 months of age, no significant differences in % or absolute number of T cells, B cells, monocytes/macrophages, or NK cells are detected in spleen and peripheral blood relative to wild-type controls

increased thymocyte number ( J:48758 )

• at 3 months of age, homozygotes display a 60% increase in thymocyte number due to a selective and transient increase in the number of double-positive thymocytes

increased double-positive T cell number ( J:48758 )

• at 3 months of age, homozygotes display a 60% increase in the number of CD4⁺ CD8⁺ T cells relative to wild-type controls

• however, this increase in only transient as normal numbers of double-positive T cell numbers are detected at both younger (4 weeks) and older ages (6 and 12 months)

hematopoietic system

increased thymocyte number ( J:48758 )

• at 3 months of age, homozygotes display a 60% increase in thymocyte number due to a selective and transient increase in the number of double-positive thymocytes

increased double-positive T cell number ( J:48758 )

• at 3 months of age, homozygotes display a 60% increase in the number of CD4⁺ CD8⁺ T cells relative to wild-type controls

• however, this increase in only transient as normal numbers of double-positive T cell numbers are detected at both younger (4 weeks) and older ages (6 and 12 months)

endocrine/exocrine glands

increased thymocyte number ( J:48758 )

• at 3 months of age, homozygotes display a 60% increase in thymocyte number due to a selective and transient increase in the number of double-positive thymocytes