Phenotypes Associated with This Genotype

Genotype
MGI:2661989

• Allelic Composition: Del(3Cd1d2-Cd1d1)1Crw/Del(3Cd1d2-Cd1d1)1Crw
• Genetic Background: involves: 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased CD4-positive, alpha-beta T cell number ( J:174337 )

• mice exhibit a reduction in the numbers of CD4+ Valpha3.2-Vbeta8 T cells compared with wild-type mice

decreased NK T cell number ( J:39749 , J:76976 , J:112657 , J:174337 )

• 60-80% reduction in NK1+ T cells, particularly those with a canonical gene rearrangement of Valpha14-Jalpha281 (J:39749)

• the percentage of NK T cells in the liver is reduced by 70% to 75% and by 60% to 75% in all other organs tested (J:76976)

• there is about a 80% reduction in the number of NK T cells found in the liver from 11.5% of total liver lymphocytes to 2.3% in the mutant liver (J:112657)

• mice exhibit a reduction of Valpha14 NKT cells in the spleen and liver compared with wild-type mice (J:174337)

abnormal NK T cell physiology ( J:112657 )

• activated NK T cells isolated from livers of these mice secrete less IFN-gamma, TNF, and IL-4 than wild-type NK T cells

abnormal antigen presentation ( J:174337 )

• thymocytes exhibit impaired antigen presentation of alphaGalCer compared with wild-type cells

decreased interleukin-4 secretion ( J:39749 )

• mutants show impaired IL-4 production after stimulation with anti-CD3 antibodies, however they are able to generate antigen-specific Th2 responses

hematopoietic system

decreased CD4-positive, alpha-beta T cell number ( J:174337 )

• mice exhibit a reduction in the numbers of CD4+ Valpha3.2-Vbeta8 T cells compared with wild-type mice

decreased NK T cell number ( J:39749 , J:76976 , J:112657 , J:174337 )

• 60-80% reduction in NK1+ T cells, particularly those with a canonical gene rearrangement of Valpha14-Jalpha281 (J:39749)

• the percentage of NK T cells in the liver is reduced by 70% to 75% and by 60% to 75% in all other organs tested (J:76976)

• there is about a 80% reduction in the number of NK T cells found in the liver from 11.5% of total liver lymphocytes to 2.3% in the mutant liver (J:112657)

• mice exhibit a reduction of Valpha14 NKT cells in the spleen and liver compared with wild-type mice (J:174337)

abnormal NK T cell physiology ( J:112657 )

• activated NK T cells isolated from livers of these mice secrete less IFN-gamma, TNF, and IL-4 than wild-type NK T cells