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Phenotypes Associated with This Genotype
Genotype
MGI:2661915
Allelic
Composition
Airetm1.1Doi/Airetm1.1Doi
Genetic
Background
involves: 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Airetm1.1Doi mutation (2 available); any Aire mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Stomach autoimmunity in Airetm1.1Doi/Airetm1.1Doi mice

immune system
• chronic inflammation of the stomach, particularly of the stomach mucosa
• thymic medullary cell (MEC) number is doubled
• near doubling of the number of activated/memory CD44hiCD62Llo T cells
• lymphatic infiltrates in specific regions of multiple organs
• infiltration is progressive with age
• autoantibodies develop against the stomach

hematopoietic system
• thymic medullary cell (MEC) number is doubled
• near doubling of the number of activated/memory CD44hiCD62Llo T cells

digestive/alimentary system
• chronic inflammation of the stomach, particularly of the stomach mucosa

endocrine/exocrine glands
• thymic medullary cell (MEC) number is doubled


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/19/2016
MGI 6.03
The Jackson Laboratory