Mouse Genome Informatics
hm
    Airetm1.1Doi/Airetm1.1Doi
involves: 129S2/SvPas * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       

Stomach autoimmunity in Airetm1.1Doi/Airetm1.1Doi mice

immune system
• chronic inflammation of the stomach, particularly of the stomach mucosa
• thymic medullary cell (MEC) number is doubled
• near doubling of the number of activated/memory CD44hiCD62Llo T cells
• lymphatic infiltrates in specific regions of multiple organs
• infiltration is progressive with age
• autoantibodies develop against the stomach

hematopoietic system
• thymic medullary cell (MEC) number is doubled
• near doubling of the number of activated/memory CD44hiCD62Llo T cells

digestive/alimentary system
• chronic inflammation of the stomach, particularly of the stomach mucosa

endocrine/exocrine glands
• thymic medullary cell (MEC) number is doubled

Mouse Models of Human Disease
OMIM IDRef(s)
Autoimmune Polyendocrine Syndrome, Type I, with or without Reversible Metaphyseal Dysplasia; APS1 240300 J:83422