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Phenotypes Associated with This Genotype
Genotype
MGI:2661915
Allelic
Composition
Airetm1.1Doi/Airetm1.1Doi
Genetic
Background
involves: 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Airetm1.1Doi mutation (2 available); any Aire mutation (52 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Stomach autoimmunity in Airetm1.1Doi/Airetm1.1Doi mice

immune system
• chronic inflammation of the stomach, particularly of the stomach mucosa
• thymic medullary cell (MEC) number is doubled
• near doubling of the number of activated/memory CD44hiCD62Llo T cells
• lymphatic infiltrates in specific regions of multiple organs
• infiltration is progressive with age
• autoantibodies develop against the stomach

hematopoietic system
• thymic medullary cell (MEC) number is doubled
• near doubling of the number of activated/memory CD44hiCD62Llo T cells

digestive/alimentary system
• chronic inflammation of the stomach, particularly of the stomach mucosa

endocrine/exocrine glands
• thymic medullary cell (MEC) number is doubled

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
autoimmune polyendocrine syndrome type 1 DOID:0050167 OMIM:240300
J:83422


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory