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Phenotypes Associated with This Genotype
Genotype
MGI:2661733
Allelic
Composition		 Acetm1Unc/Acetm1Unc
Ace2tm1Pngr/Y
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ace2tm1Pngr mutation (1 available); any Ace2 mutation (54 available)
Acetm1Unc mutation (1 available); any Ace mutation (54 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
hypotension ( J:77232 )
• similar to Acetm1Unc homozygotes however normal cardiac contractility is seen at 6 months of age unlike in Acetm1Unc homozygotes

homeostasis/metabolism
decreased angiotensin II level ( J:100334 )
• mice exposed to acid aspiration to induce acute lung injury show decreased angiotensin II levels in lung compared to single Ace2tm1Pngr mutants
decreased circulating angiotensin II level ( J:100334 )
• mice exposed to acid aspiration to induce acute lung injury show decreased angiotensin II levels in plasma compared to single Ace2tm1Pngr mutants
decreased susceptibility to injury ( J:100334 )
• mice show rescue of severe lung failure, edema formation, and histological lung changes induced by acid aspiration in single Ace2tm1Pngr mutants
• mice show rescue of the severe lung impairments seen in single Ace2tm1Pngr mutants with endotoxin-induced acute lung injury

renal/urinary system
abnormal kidney morphology ( J:77232 )
• similar to Acetm1Unc homozygotes

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory