Mouse Genome Informatics
hm
    Lystbg-slt/Lystbg-slt
YZ57/Ch
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
pigmentation
• medullary pigment was highly clumped, though individual granules could be resolved in some medullary septae
• some granules were long ovals, but irregular shapes were common
• cortical granule shape varied from oval to nearly spherical
• melanocyte pigment granules in the choroid were few in number, and were unusually large
• melanocyte pigment granules in the choroid were few in number, and were unusually large
• melanocyte pigment granules in the retina were few in number, and were unusually large
• melanocyte pigment granules in the iris were few in number, and were unusually large

vision/eye
• melanocyte pigment granules in the choroid were few in number, and were unusually large
• melanocyte pigment granules in the choroid were few in number, and were unusually large
• melanocyte pigment granules in the retina were few in number, and were unusually large
• melanocyte pigment granules in the iris were few in number, and were unusually large

integument
• medullary pigment was highly clumped, though individual granules could be resolved in some medullary septae
• some granules were long ovals, but irregular shapes were common
• cortical granule shape varied from oval to nearly spherical
• about 5% of mice lost most of the dorsum hairs of the first coat prematurely following cessation of the first hair growth cycle
• about 5% of mice lost most of the dorsum hairs of the first coat prematurely following cessation of the first hair growth cycle
• an apparently normal second coat grew in these mice but the second hair growth cycle appeared somewhat delayed

Mouse Models of Human Disease
OMIM IDRef(s)
Chediak-Higashi Syndrome; CHS 214500 J:25388