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Phenotypes Associated with This Genotype
Genotype
MGI:2661024
Allelic
Composition
Lystbg-slt/Lystbg-slt
Genetic
Background
YZ57/Ch
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lystbg-slt mutation (0 available); any Lyst mutation (47 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
pigmentation
• medullary pigment was highly clumped, though individual granules could be resolved in some medullary septae (J:25388)
• some granules were long ovals, but irregular shapes were common (J:25388)
• cortical granule shape varied from oval to nearly spherical (J:25388)
• medullary pigment was highly clumped, though individual granules could be resolved in some medullary septae (J:25388)
• some granules were long ovals, but irregular shapes were common (J:25388)
• cortical granule shape varied from oval to nearly spherical (J:25388)
• melanocyte pigment granules in the choroid were few in number, and were unusually large (J:25388)
• melanocyte pigment granules in the choroid were few in number, and were unusually large (J:25388)
• melanocyte pigment granules in the choroid were few in number, and were unusually large (J:25388)
• melanocyte pigment granules in the choroid were few in number, and were unusually large (J:25388)
• melanocyte pigment granules in the iris were few in number, and were unusually large (J:25388)
• melanocyte pigment granules in the iris were few in number, and were unusually large (J:25388)
• melanocyte pigment granules in the retina were few in number, and were unusually large (J:25388)
• melanocyte pigment granules in the retina were few in number, and were unusually large (J:25388)

vision/eye
• melanocyte pigment granules in the choroid were few in number, and were unusually large (J:25388)
• melanocyte pigment granules in the choroid were few in number, and were unusually large (J:25388)
• melanocyte pigment granules in the choroid were few in number, and were unusually large (J:25388)
• melanocyte pigment granules in the choroid were few in number, and were unusually large (J:25388)
• melanocyte pigment granules in the iris were few in number, and were unusually large (J:25388)
• melanocyte pigment granules in the iris were few in number, and were unusually large (J:25388)
• melanocyte pigment granules in the retina were few in number, and were unusually large (J:25388)
• melanocyte pigment granules in the retina were few in number, and were unusually large (J:25388)

integument
• medullary pigment was highly clumped, though individual granules could be resolved in some medullary septae (J:25388)
• some granules were long ovals, but irregular shapes were common (J:25388)
• cortical granule shape varied from oval to nearly spherical (J:25388)
• medullary pigment was highly clumped, though individual granules could be resolved in some medullary septae (J:25388)
• some granules were long ovals, but irregular shapes were common (J:25388)
• cortical granule shape varied from oval to nearly spherical (J:25388)
• about 5% of mice lost most of the dorsum hairs of the first coat prematurely following cessation of the first hair growth cycle (J:83269)
• about 5% of mice lost most of the dorsum hairs of the first coat prematurely following cessation of the first hair growth cycle (J:83269)
• about 5% of mice lost most of the dorsum hairs of the first coat prematurely following cessation of the first hair growth cycle (J:83269)
• an apparently normal second coat grew in these mice but the second hair growth cycle appeared somewhat delayed (J:83269)
• about 5% of mice lost most of the dorsum hairs of the first coat prematurely following cessation of the first hair growth cycle (J:83269)
• an apparently normal second coat grew in these mice but the second hair growth cycle appeared somewhat delayed (J:83269)

Mouse Models of Human Disease
OMIM ID Ref(s)
Chediak-Higashi Syndrome; CHS 214500 J:25388


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory