Phenotypes Associated with This Genotype

Genotype
MGI:2660901

• Allelic Composition: Szt1/Szt1⁺
• Genetic Background: involves: BALB/cByJ * BALB/cJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal seizure response to pharmacological agent ( J:82964 )

• low thresholds for PTZ induced tonic-clonic seizures

abnormal seizure response to electrical stimulation ( J:82964 )

• low thresholds for minimal electroconvulsive induced tonic-clonic seizures

growth/size/body

decreased body weight ( J:82964 )

• heterozygotes weighed 4-8% less than wild-type littermates

decreased body length ( J:82964 )

• measurements showed heterozygotes were 3-5% shorter than wild-type controls

nervous system

abnormal seizure response to pharmacological agent ( J:82964 )

• low thresholds for PTZ induced tonic-clonic seizures

abnormal seizure response to electrical stimulation ( J:82964 )

• low thresholds for minimal electroconvulsive induced tonic-clonic seizures

abnormal hippocampus CA3 region morphology ( J:82964 )

• gross examination revealed a malformed CA3 region between the two dentate gyrus blades

decreased hippocampus pyramidal cell number ( J:82964 )

• hippocampus contained ~40% fewer pyramidal neurons