Analysis Tools
mortality/aging
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• less than half of the birthed pups survived to adulthood
|
|
• greater than 60% died in utero
|
embryo
endocrine/exocrine glands
 |
• hyperplastic sex cord derivatives resulted in ovaries that were 5 times larger by 8 months of age
|
small ovary
(
J:46239
)
|
|
• prior to hyperplasia, the ovaries were smaller than those of wild-type
|
small testis
(
J:46239
)
 |
• approximately 1/3 the size of wild-type
|
growth/size/body
|
|
• hyperplastic sex cord derivatives resulted in ovaries that were 5 times larger by 8 months of age
|
reproductive system
|
• reduced number of primordial germ cells at the genital ridge at E11.5 and E13.5, putatively due to apoptosis
• no ectopic PGCs were observed
• germ cells were absent from the seminferous tubules
|
|
|
• hyperplastic sex cord derivatives resulted in ovaries that were 5 times larger by 8 months of age
|
small ovary
(
J:46239
)
|
|
• prior to hyperplasia, the ovaries were smaller than those of wild-type
|
small testis
(
J:46239
)
|
|
• approximately 1/3 the size of wild-type
|
cellular
|
• reduced number of primordial germ cells at the genital ridge at E11.5 and E13.5, putatively due to apoptosis
• no ectopic PGCs were observed
• germ cells were absent from the seminferous tubules
|
