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Phenotypes Associated with This Genotype
Genotype
MGI:2660790
Allelic
Composition		 Fanclgcd/Fancltm1Ceb
Genetic
Background		 involves: 129/Sv * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fanclgcd mutation (0 available); any Fancl mutation (28 available)
Fancltm1Ceb mutation (0 available); any Fancl mutation (28 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
abnormal Sertoli cell morphology ( J:80424 )
• >90% of seminiferous tubules contained vacuolated sertoli cells
small testis ( J:80424 )
• approximately 1/3 the size of wild-type

reproductive system
absent germ cells ( J:80424 )
• deficiency observed at 10.5 dpc
abnormal Sertoli cell morphology ( J:80424 )
• >90% of seminiferous tubules contained vacuolated sertoli cells
small testis ( J:80424 )
• approximately 1/3 the size of wild-type

cellular
absent germ cells ( J:80424 )
• deficiency observed at 10.5 dpc

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory