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Phenotypes Associated with This Genotype
Genotype
MGI:2660751
Allelic
Composition
Fanclgcd/Fanclgcd
Genetic
Background
involves: C57BL/6J * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fanclgcd mutation (0 available); any Fancl mutation (14 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Histological sections of adult Fanclgcd/Fanclgcd mouse gonads

endocrine/exocrine glands
• reduced complexity of uterine glands
• only a few corpora lutea are detected at 2.5 and 5 months of age
(J:13553)
• significant absence of developing follicles at 2.5 and 5 months of age (J:21254)
(J:13553)
• 80-90% reduction in mass relative to controls (J:21254)
• hemorrhagic cysts were observed
• 50-70% of the tubules lacked all cells but sertioli, however normal weight and histology of seminal vesicles, coagulating glands, prostate, bulbourethral glands, and preputial glands
• testicular mass was approximately 1/3 that of controls

homeostasis/metabolism

reproductive system
• sperm counts were 10% of those of wild-type
• depletion evident at 10.25 dpc, when mice had approximatly 1/3 the primordial germ cells as wild-type (J:80424)
• reduced primordial germ cell (PGC) prolifertation
• normal PGC migration
• 50-70% of the tubules lacked all cells but sertioli, however normal weight and histology of seminal vesicles, coagulating glands, prostate, bulbourethral glands, and preputial glands
• testicular mass was approximately 1/3 that of controls
• the female reproductive tract is pale, thin, and thread-like with a castrate appearance
• reduced complexity of uterine glands
• only a few corpora lutea are detected at 2.5 and 5 months of age
(J:13553)
• significant absence of developing follicles at 2.5 and 5 months of age (J:21254)
(J:13553)
• 80-90% reduction in mass relative to controls (J:21254)
• hemorrhagic cysts were observed
(J:13553)
• the thickness of the muscularis externa is significantly reduced (J:21254)
• 80-90% reduction in mass relative to controls
• reduced thickness of serosa, myometrium, and endometrium (J:13553)
• reduced complexity of uterine glands (J:13553)
• 80-90% reduction in mass relative to controls (J:21254)
• epididymal mass was approximately 1/3 that of controls
• reduced ovulation observed in prepubertal females after superovulation regime
• no ovulation observed in postpubertal females after superovulation regime
• females initially exhibit a normal 4-5 day cycle, but begin to cycle irregularly by 6-8 weeks of age
• absence of oestrus cycling by 20 weeks of age
• females are infertile, however mutant mice display normal sexual development in terms of sexual behavior and mammary gland histology (J:13553)
• females are infertile however have normal timing of vaginal opening (J:21254)

cellular
• sperm counts were 10% of those of wild-type
• depletion evident at 10.25 dpc, when mice had approximatly 1/3 the primordial germ cells as wild-type (J:80424)
• reduced primordial germ cell (PGC) prolifertation
• normal PGC migration

Mouse Models of Human Disease
OMIM ID Ref(s)
Ovarian Dysgenesis 1; ODG1 233300 J:13553


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/13/2016
MGI 6.05
The Jackson Laboratory