Mouse Genome Informatics
hm
    Fanclgcd/Fanclgcd
involves: C57BL/6J * CBA/J
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       

Histological sections of adult Fanclgcd/Fanclgcd mouse gonads

endocrine/exocrine glands
• only a few corpora lutea are detected at 2.5 and 5 months of age (J:21254)
(J:13553)
• significant absence of developing follicles at 2.5 and 5 months of age (J:21254)
(J:13553)
• 80-90% reduction in mass relative to controls (J:21254)
• hemorrhagic cysts were observed (J:21254)
• 50-70% of the tubules lacked all cells but sertioli, however normal weight and histology of seminal vesicles, coagulating glands, prostate, bulbourethral glands, and preputial glands (J:21254)
• testicular mass was approximately 1/3 that of controls (J:21254)

homeostasis/metabolism

reproductive system
• reduced primordial germ cell (PGC) prolifertation
• normal PGC migration
• 50-70% of the tubules lacked all cells but sertioli, however normal weight and histology of seminal vesicles, coagulating glands, prostate, bulbourethral glands, and preputial glands (J:21254)
• testicular mass was approximately 1/3 that of controls (J:21254)
• the female reproductive tract is pale, thin, and thread-like with a castrate appearance (J:21254)
• only a few corpora lutea are detected at 2.5 and 5 months of age (J:21254)
(J:13553)
• significant absence of developing follicles at 2.5 and 5 months of age (J:21254)
(J:13553)
• 80-90% reduction in mass relative to controls (J:21254)
• hemorrhagic cysts were observed (J:21254)
• reduced complexity of uterine glands (J:13553)
(J:13553)
• the thickness of the muscularis externa is significantly reduced (J:21254)
• 80-90% reduction in mass relative to controls (J:21254)
• reduced thickness of serosa, myometrium, and endometrium (J:13553)
• reduced complexity of uterine glands (J:13553)
• 80-90% reduction in mass relative to controls (J:21254)
• sperm counts were 10% of those of wild-type (J:21254)
• depletion evident at 10.25 dpc, when mice had approximatly 1/3 the primordial germ cells as wild-type (J:80424)
• epididymal mass was approximately 1/3 that of controls (J:21254)
• reduced ovulation observed in prepubertal females after superovulation regime (J:13553)
• no ovulation observed in postpubertal females after superovulation regime (J:13553)
• females initially exhibit a normal 4-5 day cycle, but begin to cycle irregularly by 6-8 weeks of age (J:13553)
• absence of oestrus cycling by 20 weeks of age (J:13553)
• females are infertile, however mutant mice display normal sexual development in terms of sexual behavior and mammary gland histology (J:13553)
• females are infertile however have normal timing of vaginal opening (J:21254)
(J:21254)

cellular
• reduced primordial germ cell (PGC) prolifertation
• normal PGC migration

Mouse Models of Human Disease
OMIM IDRef(s)
Ovarian Dysgenesis 1; ODG1 233300 J:13553