Phenotypes Associated with This Genotype

Genotype
MGI:2660729

• Allelic Composition: Pou3f2^tm1Rsd/Pou3f2^tm1Rsd; Pou3f3^tm1Rmc/Pou3f3^tm1Rmc
• Genetic Background: involves: 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:74989 )

• double homozygotes were not viable at birth

nervous system

abnormal cerebellum development ( J:74989 )

abnormal forebrain morphology ( J:74989 )

• double homozygotes displayed abnormalities in axonal outgrowth and projection in the forebrain

abnormal olfactory bulb development ( J:74989 )

abnormal cerebral cortex morphology ( J:74989 )

• double homozygotes displayed abnormal organization of cortical lamination with delayed radial migration of layers II/III

abnormal stratification in cerebral cortex ( J:74989 )

• double homozygotes displayed inversion of cortical layers II-V through aberrant regulation of the p39/p35 regulatory components of CDK5