Phenotypes Associated with This Genotype

Genotype
MGI:2660691

• Allelic Composition: plt/plt
• Genetic Background: involves: DDD/1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal leukocyte cell number ( J:47819 )

decreased T cell number ( J:47819 )

• the total number of T cells in lymph nodes is smaller than in BALB/c mice

decreased single-positive T cell number ( J:15290 )

• the number of either CD4+ or CD8+ T cells is decreased compared to in CBA, B6, C3H and BALB/c mice

increased T cell number ( J:47819 )

• the number of T cells in the blood and spleen is increased compared to in wild-type mice

increased memory T cell number ( J:47460 )

• the number of T cells in the peripheral lymph nodes and Peyer's patches with memory phenotype is increased compared to in wild-type mice

abnormal immune system organ morphology ( J:47819 )

abnormal spleen red pulp morphology ( J:47460 )

• unlike in wild-type spleens, T cells are found within the red pulp

abnormal spleen white pulp morphology ( J:47460 )

• unlike in wild-type spleens, few T cells are found within the white pulp

small Peyer's patches ( J:47460 )

• most Peyer's patches are smaller than in wild-type mice

abnormal lymph node T cell domain morphology ( J:47460 , J:47819 )

• T cells are hardly observed in T cell zones but are observed in B cell zones (J:47460)

• low density of T cells in subcortical area (J:47819)

lymph node hypoplasia ( J:47460 , J:15290 )

• T cell cellularity within the peripheral lymph nodes is decreased (J:47460)

• the number of lymph node cells is reduced by 10 and 6 times in males and females, respectively, than in CBA and B6 mice (J:15290)

abnormal peripheral lymph node morphology ( J:47819 )

• the amount of T cells in the subcortical area is extremely low

abnormal immune system physiology ( J:47819 )

abnormal leukocyte migration ( J:47460 , J:47819 )

• T cell migration into peripheral lymph nodes, Peyer's patches and the spleen is defective (J:47460)

• however, neutrophil and macrophage recruitment stimulated by thioglycolate is normal (J:47460)

• T cell migration into lymph nodes is defective (J:47819)

hematopoietic system

abnormal leukocyte migration ( J:47460 , J:47819 )

• T cell migration into peripheral lymph nodes, Peyer's patches and the spleen is defective (J:47460)

• however, neutrophil and macrophage recruitment stimulated by thioglycolate is normal (J:47460)

• T cell migration into lymph nodes is defective (J:47819)

abnormal leukocyte cell number ( J:47819 )

decreased T cell number ( J:47819 )

• the total number of T cells in lymph nodes is smaller than in BALB/c mice

decreased single-positive T cell number ( J:15290 )

• the number of either CD4+ or CD8+ T cells is decreased compared to in CBA, B6, C3H and BALB/c mice

increased T cell number ( J:47819 )

• the number of T cells in the blood and spleen is increased compared to in wild-type mice

increased memory T cell number ( J:47460 )

• the number of T cells in the peripheral lymph nodes and Peyer's patches with memory phenotype is increased compared to in wild-type mice

abnormal spleen red pulp morphology ( J:47460 )

• unlike in wild-type spleens, T cells are found within the red pulp

abnormal spleen white pulp morphology ( J:47460 )

• unlike in wild-type spleens, few T cells are found within the white pulp

cellular

abnormal leukocyte migration ( J:47460 , J:47819 )

• T cell migration into peripheral lymph nodes, Peyer's patches and the spleen is defective (J:47460)

• however, neutrophil and macrophage recruitment stimulated by thioglycolate is normal (J:47460)

• T cell migration into lymph nodes is defective (J:47819)