Phenotypes Associated with This Genotype

Genotype
MGI:2660685

• Allelic Composition: Ccl2^tm1Rol/Ccl2^tm1Rol
• Genetic Background: involves: 129S4/SvJae * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

impaired macrophage chemotaxis ( J:45920 )

• impaired macrophage recruitment following intraperitoneal thioglycollate injection

abnormal monocyte morphology ( J:45920 )

• mutants are unable to recruit monocytes 72 hours after intraperitoneal thioglycollate administration despite normal numbers of circulating leukocytes and macrophages

decreased susceptibility to type IV hypersensitivity reaction ( J:45920 )

• accumulation of F4/80+ monocytes in delayed-type hypersensitivity lesions is impaired, although the swelling response is normal

• development of secondary pulmonary granulomata in response to Schistosoma mansoni eggs in blunted

decreased interferon-gamma secretion ( J:45920 )

• IFN-gamma secretion is 59% lower in mutant splenocytes

decreased interleukin-4 secretion ( J:45920 )

• IL-4 production is reduced in splenocytes

decreased interleukin-5 secretion ( J:45920 )

• IL-5 production is reduced in splenocytes

hematopoietic system

impaired macrophage chemotaxis ( J:45920 )

• impaired macrophage recruitment following intraperitoneal thioglycollate injection

abnormal monocyte morphology ( J:45920 )

• mutants are unable to recruit monocytes 72 hours after intraperitoneal thioglycollate administration despite normal numbers of circulating leukocytes and macrophages

cellular

impaired macrophage chemotaxis ( J:45920 )

• impaired macrophage recruitment following intraperitoneal thioglycollate injection