Phenotypes for Tlr9 MGI:2660568 MGI Mouse

immune system phenotype ( J:66049 )

N	• normal lymphocyte composition, as assessed by flow cytometry

abnormal B cell physiology ( J:66049 )

• impaired MHC class II expression in response to CpG DNA

abnormal T-helper 1 physiology ( J:66049 )

• no observed CpG-DNA-induced Th1-like response in vivo

abnormal macrophage physiology ( J:66049 , J:117688 )

• impaired ability to produce IL6, IL12 and TNF-alpha in response to CpG DNA (J:66049)

• production of IL6, IL12, and TNF-alpha in response to LPS, PGN, lipoprotein from Escherichia coli, zymosan, and heat-killed Staphylococcus aureus was comparable to wild-type controls (J:66049)

• response to CpG is considerably decreased compared to wild-type (J:117688)

abnormal dendritic cell physiology ( J:66049 )

• impaired production of IL12 in response to CpG DNA, but not LPS

• impaired expression of CD40, CD80, CD86, and MHC II in response to CpG DNA, but not LPS

decreased inflammatory response ( J:66049 )

• resistant to CpG-DNA-induced shock syndrome compared to wild-type mice

• unlike wild-type controls, no increase in serum IL6, IL12, or TNF-alpha in response to CpG-DNA in vivo