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Phenotypes Associated with This Genotype
Genotype
MGI:2660568
Allelic
Composition
Tlr9tm1Aki/Tlr9tm1Aki
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tlr9tm1Aki mutation (4 available); any Tlr9 mutation (40 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• normal lymphocyte composition, as assessed by flow cytometry
• impaired MHC class II expression in response to CpG DNA
• no observed CpG-DNA-induced Th1-like response in vivo
• impaired ability to produce IL6, IL12 and TNF-alpha in response to CpG DNA (J:66049)
• production of IL6, IL12, and TNF-alpha in response to LPS, PGN, lipoprotein from Escherichia coli, zymosan, and heat-killed Staphylococcus aureus was comparable to wild-type controls (J:66049)
• response to CpG is considerably decreased compared to wild-type (J:117688)
• impaired production of IL12 in response to CpG DNA, but not LPS
• impaired expression of CD40, CD80, CD86, and MHC II in response to CpG DNA, but not LPS
• resistant to CpG-DNA-induced shock syndrome compared to wild-type mice
• unlike wild-type controls, no increase in serum IL6, IL12, or TNF-alpha in response to CpG-DNA in vivo

hematopoietic system
• impaired MHC class II expression in response to CpG DNA
• no observed CpG-DNA-induced Th1-like response in vivo
• impaired ability to produce IL6, IL12 and TNF-alpha in response to CpG DNA (J:66049)
• production of IL6, IL12, and TNF-alpha in response to LPS, PGN, lipoprotein from Escherichia coli, zymosan, and heat-killed Staphylococcus aureus was comparable to wild-type controls (J:66049)
• response to CpG is considerably decreased compared to wild-type (J:117688)


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory