Phenotypes Associated with This Genotype

Genotype
MGI:2659102

• Allelic
  Composition
• Genetic Background: CAST/EiJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased susceptibility to Coronaviridae infection ( J:268979 )

• highly susceptible to mouse-adapted SARS-CoV infection, including substantial weight loss and death

increased susceptibility to Coronaviridae infection induced morbidity/mortality ( J:268979 )

nervous system

abnormal axon extension ( J:220890 )

abnormal central nervous system regeneration ( J:220890 )

• dorsal root ganglion neurons exhibit an improved ability to regenerate axons in an inhibitory environment as measured by an increase in the number of neurons with neurites and the increased length of axonal process per neuron under both naive and pre-injured conditions as compared to A/J, C3H/HeJ, C57BL/6J, DBA/2J, 129S1/SvImJ, NOD/LtJ, NZO/HlLtJ, and WSB/EiJ

• neurons exhibit more extensive axonal regeneration in the spinal cord and optic nerve following injury as compared to C57BL/6

abnormal collateral sprouting ( J:220890 )

• axonal sprouting is enhanced following ischemic stroke as compared to C57BL/6

cellular

abnormal axon extension ( J:220890 )

mortality/aging

increased susceptibility to Coronaviridae infection induced morbidity/mortality ( J:268979 )