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Phenotypes Associated with This Genotype
Genotype
MGI:2659102
Allelic
Composition
Genetic
Background
CAST/EiJ
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No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• highly susceptible to mouse-adapted SARS-CoV infection, including substantial weight loss and death

nervous system
• dorsal root ganglion neurons exhibit an improved ability to regenerate axons in an inhibitory environment as measured by an increase in the number of neurons with neurites and the increased length of axonal process per neuron under both naive and pre-injured conditions as compared to A/J, C3H/HeJ, C57BL/6J, DBA/2J, 129S1/SvImJ, NOD/LtJ, NZO/HlLtJ, and WSB/EiJ
• neurons exhibit more extensive axonal regeneration in the spinal cord and optic nerve following injury as compared to C57BL/6
• axonal sprouting is enhanced following ischemic stroke as compared to C57BL/6

cellular

mortality/aging


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/07/2021
MGI 6.17
The Jackson Laboratory