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Phenotypes Associated with This Genotype
Genotype
MGI:2659051
Allelic
Composition		 Dazltm1Hjc/Dazltm1Hjc
Genetic
Background		 involves: 129P2/OlaHsd * MF1
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Mouse lines carrying:
Dazltm1Hjc mutation (3 available); any Dazl mutation (30 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
absent ovarian follicles ( J:42612 )
• neither follicles nor ova were observed
abnormal seminiferous tubule morphology ( J:42612 , J:71070 )
• fewer tubules per cross-section (J:42612)
• reduced tubule diameter relative to wild-type (J:71070)
small testis ( J:42612 )
• 3-fold reduction in testis mass relative to wild-type littermates

reproductive system
absent ovarian follicles ( J:42612 )
• neither follicles nor ova were observed
abnormal seminiferous tubule morphology ( J:42612 , J:71070 )
• fewer tubules per cross-section (J:42612)
• reduced tubule diameter relative to wild-type (J:71070)
small testis ( J:42612 )
• 3-fold reduction in testis mass relative to wild-type littermates
arrest of spermatogenesis ( J:42612 , J:71070 )
(J:42612)
• spermatogonia were contained within 76% of adult tubules (J:71070)
• spermatocytes were contained within 3% of adult tubules (J:71070)
• failure of A aligned spermatogonia to differentiate into A1 spermatogonia (J:71070)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory