Phenotypes Associated with This Genotype

Genotype
MGI:2658864

• Allelic Composition: Bub3^tm1Khac/Bub3^tm1Khac
• Genetic Background: either: (involves: 129P2/OlaHsd) or (involves: 129S1/Sv)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:64874 )

• embryos appear normal up to day 3.5 pc but accumulate mitotic errors from days 4.5-6.5 and die before day 8.5

• embryos are viable at day 3.5 in utero and persist in culture through day 3.5-7.5

embryo

inner cell mass degeneration ( J:64874 )

• smaller in size and degenerating by E6.5

• the trophectoderm appears normal

cellular

abnormal cell nucleus morphology ( J:64874 )

• by E6.5, nuclear morphology is grossly abnormal

• by E4.5, an increased number of micronuclei are observed

abnormal chromosome morphology ( J:64874 )

• at E6.5, lagging chromosomes and chromatin bridging are observed