Analysis Tools
mortality/aging
|
• mutants die at early maturity
|
craniofacial
|
• all craniofacial variables are significantly smaller in mutant mice compared with normal mice
|
|
• data reveals sagittal growth deficiency in the anterior cranial base
|
|
• the top but not the back of the cranium is rounded compared with normal mice
|
long incisors
(
J:15489
)
|
• due to malocclusion; if left untrimmed, incisors continue to grow and eventually curve inward, piercing the oral tissues and preventing ingestion
|
|
• incisors do not wear down during mastication, presumably due to incisal malocclusion
|
malocclusion
(
J:15489
)
|
• this condition is chronic and teeth must be cut on a regular basis to allow mice to eat
• this condition allows accurate identification of adult mutant mice
|
|
• condyles and necks of mutant mice are typically smaller and thinner compared with normal mice
|
|
• processes of mutant mice are smaller and shorter while projecting superiorly rather than posterosuperiorly as in control mice
|
|
• newborns display some midfacial shortening
(J:47869)
• all facial bones are shortened
(J:15489)
|
|
• newborns display evidence of median cleft lip
(J:47869)
• deeper than usual midline cleft of the upper lip
(J:13450)
|
short snout
(
J:13450
)
|
• noticeable at birth
|
growth/size/body
long incisors
(
J:15489
)
|
• due to malocclusion; if left untrimmed, incisors continue to grow and eventually curve inward, piercing the oral tissues and preventing ingestion
|
|
• incisors do not wear down during mastication, presumably due to incisal malocclusion
|
malocclusion
(
J:15489
)
|
• this condition is chronic and teeth must be cut on a regular basis to allow mice to eat
• this condition allows accurate identification of adult mutant mice
|
|
• condyles and necks of mutant mice are typically smaller and thinner compared with normal mice
|
|
• processes of mutant mice are smaller and shorter while projecting superiorly rather than posterosuperiorly as in control mice
|
|
• newborns display some midfacial shortening
(J:47869)
• all facial bones are shortened
(J:15489)
|
|
• newborns display evidence of median cleft lip
(J:47869)
• deeper than usual midline cleft of the upper lip
(J:13450)
|
short snout
(
J:13450
)
|
• noticeable at birth
|
kidney cyst
(
J:71108
)
|
• kidneys of newborns have a rough and irregular surface indicative of multifocal cyst formation in underlying tubules
|
renal/urinary system
|
• few glomeruli
|
kidney cyst
(
J:71108
)
|
• kidneys of newborns have a rough and irregular surface indicative of multifocal cyst formation in underlying tubules
|
small kidney
(
J:13450
)
pale kidney
(
J:13450
)
skeleton
|
• all craniofacial variables are significantly smaller in mutant mice compared with normal mice
|
|
• data reveals sagittal growth deficiency in the anterior cranial base
|
|
• the top but not the back of the cranium is rounded compared with normal mice
|
long incisors
(
J:15489
)
|
• due to malocclusion; if left untrimmed, incisors continue to grow and eventually curve inward, piercing the oral tissues and preventing ingestion
|
|
• incisors do not wear down during mastication, presumably due to incisal malocclusion
|
malocclusion
(
J:15489
)
|
• this condition is chronic and teeth must be cut on a regular basis to allow mice to eat
• this condition allows accurate identification of adult mutant mice
|
|
• condyles and necks of mutant mice are typically smaller and thinner compared with normal mice
|
|
• processes of mutant mice are smaller and shorter while projecting superiorly rather than posterosuperiorly as in control mice
|
digestive/alimentary system
