Phenotypes Associated with This Genotype

Genotype
MGI:2657249

• Allelic Composition: Igk^tm1Dhu/Igk^tm1Dhu; Iglc1^tm2Ust/Iglc1^tm2Ust
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal B cell differentiation ( J:74717 )

• generation of immature lamda1 B cells in the bone marrow and their continued maturation to mature B cells in the spleen are defective

decreased immature B cell number ( J:74717 )

• number of immature lamda 1 B cells is decreased 2- to 3-fold in the bone marrow

decreased transitional stage T1 B cell number ( J:74717 )

• 3-fold decrease in lamda 1 transitional type 1 (T1) B cells

decreased transitional stage T2 B cell number ( J:74717 )

• 10-fold decrease in the number of transitional 2 (T2) lamda 1 B cells

decreased B cell number ( J:74717 )

• reduced numbers of immature lambda 1 B cells in bone marrow and reduced numbers of mature lambda 1 B cells in spleen

decreased mature B cell number ( J:74717 )

• 6-fold decrease in the number of mature lamda 1 B cells

• number of recirculating mature lamda 1 B cells in the bone marrow is decreased 7- to 20-fold

decreased marginal zone B cell number ( J:74717 )

• decrease in marginal zone lamda 1 B cells

hematopoietic system

abnormal B cell differentiation ( J:74717 )

• generation of immature lamda1 B cells in the bone marrow and their continued maturation to mature B cells in the spleen are defective

decreased immature B cell number ( J:74717 )

• number of immature lamda 1 B cells is decreased 2- to 3-fold in the bone marrow

decreased transitional stage T1 B cell number ( J:74717 )

• 3-fold decrease in lamda 1 transitional type 1 (T1) B cells

decreased transitional stage T2 B cell number ( J:74717 )

• 10-fold decrease in the number of transitional 2 (T2) lamda 1 B cells

decreased B cell number ( J:74717 )

• reduced numbers of immature lambda 1 B cells in bone marrow and reduced numbers of mature lambda 1 B cells in spleen

decreased mature B cell number ( J:74717 )

• 6-fold decrease in the number of mature lamda 1 B cells

• number of recirculating mature lamda 1 B cells in the bone marrow is decreased 7- to 20-fold

decreased marginal zone B cell number ( J:74717 )

• decrease in marginal zone lamda 1 B cells