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Phenotypes Associated with This Genotype
Genotype
MGI:2657244
Allelic
Composition
Hpgdtm1Bhk/Hpgdtm1Bhk
Genetic
Background
involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hpgdtm1Bhk mutation (1 available); any Hpgd mutation (7 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• homozygotes die within 12-48 hours after birth
• administration of indomethacin, which inhibits PGE2 production, rescues neonatal lethality and ductus arteriosus patency

cardiovascular system
• newborn homozygotes fail to exhibit remodeling of the ductus arteriosus i.e. lifting of endothelial cells, fragmentation of elastic lamina, migration of smooth-muscle cells and obstruction of lumen by intimal thickening
• newborn homozygotes exhibit a patent ductus arteriosus of a similar diameter to that of a full-term fetus
• newborn homozygotes die of congestive heart failure as a result of left-ventricle overload and exposure of the right ventricle to arterial pressures

homeostasis/metabolism
• newborn homozygotes exhibit significantly increased PGE2 levels; in contrast, TxB2 levels remain normal
• perinatal PGE2 levels remain abnormally elevated, intracellular cAMP levels do not change, and DA remodeling is inhibited

cellular
• newborn homozygotes fail to exhibit remodeling of the ductus arteriosus i.e. lifting of endothelial cells, fragmentation of elastic lamina, migration of smooth-muscle cells and obstruction of lumen by intimal thickening
• newborn homozygotes exhibit a patent ductus arteriosus of a similar diameter to that of a full-term fetus


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory