Phenotypes for Ahr Nfe2l2 MGI:2657005 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Ahr^tm1Yfk/Ahr^tm1Yfk Nfe2l2^tm1Mym/Nfe2l2^tm1Mym
Genetic Background	involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6J * ICR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ahr^tm1Yfk mutation (5 available); any Ahr mutation (109 available)
Nfe2l2^tm1Mym mutation (5 available); any Nfe2l2 mutation (94 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

decreased survivor rate ( J:82937 )

• 40% survival rate after 400 days

postnatal lethality, incomplete penetrance ( J:82937 )

• 50% of animals die within 1 week after birth for unknown reasons

homeostasis/metabolism

abnormal xenobiotic pharmacokinetics ( J:82937 )

• altered metabolism of phenobarbital and butylated hydroxyanisole (BHA)

liver/biliary system

hepatic steatosis ( J:82937 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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