Phenotypes Associated with This Genotype

Genotype
MGI:2656984

• Allelic Composition: Socs1^tm1Wehi/Socs1^tm3Wehi; Tg(Lck-cre)I57Jxm/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * ICR

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

enlarged thymus medulla ( J:83009 )

• enlarged thymic medulla

thymus hyperplasia ( J:83009 )

• increase in thymus cellularity predominately due to an increase in CD8+ T cell population

abnormal T cell differentiation ( J:83009 )

• enhanced differentiation of thymocytes toward CD8+ T cells

decreased B cell number ( J:83009 )

• large reduction in the percentage of non-T cells, mostly B cells, in the lymph nodes

abnormal T cell subpopulation ratio ( J:83009 )

• increase in the ratio of mature CD8 single positive:CD4 single positive thymocytes from 1:4 to 1:1

• increase in the ratio of CD8+:CD4+ T cells in the spleen, however total numbers of T cells are unchanged

abnormal CD4-positive, alpha beta T cell morphology ( J:83009 )

• mature thymocytes, both CD4 single positive and CD8 single positive, are larger in size

increased CD4-positive, alpha-beta T cell number ( J:83009 )

• increase in CD4+ T cells in the blood

abnormal CD8-positive, alpha beta T cell morphology ( J:83009 )

• mature thymocytes, both CD4 single positive and CD8 single positive, are larger in size

increased CD8-positive, alpha-beta T cell number ( J:83009 )

• large increase in the percentage and number of CD8 single positive thymocytes at 6 weeks of age

• increase in CD8+ T cells in the blood

abnormal T cell activation ( J:83009 )

• almost all peripheral CD8+ T cells but not CD4+ T cells appear as CD44^ho, indicating that they exhibit a memory rather than activated phenotype

enlarged lymph nodes ( J:83009 )

lymph node hyperplasia ( J:83009 )

• lymph nodes contain 2-fold the number of cells in controls

hematopoietic system

enlarged thymus medulla ( J:83009 )

• enlarged thymic medulla

thymus hyperplasia ( J:83009 )

• increase in thymus cellularity predominately due to an increase in CD8+ T cell population

abnormal T cell differentiation ( J:83009 )

• enhanced differentiation of thymocytes toward CD8+ T cells

decreased B cell number ( J:83009 )

• large reduction in the percentage of non-T cells, mostly B cells, in the lymph nodes

abnormal T cell subpopulation ratio ( J:83009 )

• increase in the ratio of mature CD8 single positive:CD4 single positive thymocytes from 1:4 to 1:1

• increase in the ratio of CD8+:CD4+ T cells in the spleen, however total numbers of T cells are unchanged

abnormal CD4-positive, alpha beta T cell morphology ( J:83009 )

• mature thymocytes, both CD4 single positive and CD8 single positive, are larger in size

increased CD4-positive, alpha-beta T cell number ( J:83009 )

• increase in CD4+ T cells in the blood

abnormal CD8-positive, alpha beta T cell morphology ( J:83009 )

• mature thymocytes, both CD4 single positive and CD8 single positive, are larger in size

increased CD8-positive, alpha-beta T cell number ( J:83009 )

• large increase in the percentage and number of CD8 single positive thymocytes at 6 weeks of age

• increase in CD8+ T cells in the blood

abnormal T cell activation ( J:83009 )

• almost all peripheral CD8+ T cells but not CD4+ T cells appear as CD44^ho, indicating that they exhibit a memory rather than activated phenotype

endocrine/exocrine glands

enlarged thymus medulla ( J:83009 )

• enlarged thymic medulla

thymus hyperplasia ( J:83009 )

• increase in thymus cellularity predominately due to an increase in CD8+ T cell population