Phenotypes Associated with This Genotype

Genotype
MGI:2656914

• Allelic Composition: Sgca^tm1Eeng/Sgca^tm1Eeng
• Genetic Background: involves: 129S/SvEv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

muscle

impaired skeletal muscle contractility ( J:83034 )

• muscle extensibility is decreased in skeletal muscle

• muscle force-generating capacity of diaphragm muscle is depressed

• mice show a loss of coupling between transverse passive stress and contractile muscle force

• skeletal muscles are stiffer in the axial, as well as in the transverse, direction to the muscle fibers

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
autosomal recessive limb-girdle muscular dystrophy type 2D		DOID:0110278	OMIM:608099	J:83034