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Phenotypes Associated with This Genotype
Genotype
MGI:2656914
Allelic
Composition
Sgcatm1Eeng/Sgcatm1Eeng
Genetic
Background
involves: 129S/SvEv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sgcatm1Eeng mutation (0 available); any Sgca mutation (14 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
muscle
• muscle extensibility is decreased in skeletal muscle
• muscle force-generating capacity of diaphragm muscle is depressed
• mice show a loss of coupling between transverse passive stress and contractile muscle force
• skeletal muscles are stiffer in the axial, as well as in the transverse, direction to the muscle fibers

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
autosomal recessive limb-girdle muscular dystrophy type 2D DOID:0110278 OMIM:608099
J:83034


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/16/2017
MGI 6.09
The Jackson Laboratory