Analysis Tools
immune system
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• mastocytosis in lungs of infected mice does not occur in mutants; 8-fold fewer mast cells are found compared to wild-type
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• granulomas of equivalent size and granularity develop in mutants and wild-type upon infection with parasite eggs
(J:82881)
• a secondary challenge induces equivalent levels of goblet cell and mast cell induction, as in wild-type
(J:82881)
• upon infection with Schistosoma mansoni eggs, primary granuloma formation and volume is equivalent to wild-type
(J:113543)
• volumes of secondary granulomas after second exposure with parasite eggs are similar to wild-type
(J:113543)
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• after primary infection with Schistosoma mansoni eggs, expansion of goblet cell population in airways and mast cell population in lungs does not occur, in contrast to wild-type response
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• upon nematode infection (N. brasiliensis), fewer goblet cells are found in mutants
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digestive/alimentary system
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• after primary challenge with parasite eggs, goblet cell hyperplasia along the airway epithelia does not develop like in wild-type; mutants have 10-fold fewer goblet cells than wild-type
• upon nematode infection (N. brasiliensis), fewer goblet cells are found in mutants
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hematopoietic system
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• mastocytosis in lungs of infected mice does not occur in mutants; 8-fold fewer mast cells are found compared to wild-type
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homeostasis/metabolism
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• in jejunal homogenates, mast cell protease (mMCP-1) activity is reduced compared to wild-type after nematode infection
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cellular
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• after primary challenge with parasite eggs, goblet cell hyperplasia along the airway epithelia does not develop like in wild-type; mutants have 10-fold fewer goblet cells than wild-type
• upon nematode infection (N. brasiliensis), fewer goblet cells are found in mutants
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