Phenotypes Associated with This Genotype

Genotype
MGI:2656271

• Allelic Composition: Gja8^tm1(Gja3)Tww/Gja8^tm1(Gja3)Tww
• Genetic Background: involves: 129S/SvEv

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

small lens ( J:73875 )

• at P7, mutant lenses are proportionately smaller but show normal cellular histology

• by P14, the mutant lens mass is reduced by 34% relative to the wild-type

• however, no significant differences in lens mass are noted at P0, and eye and lens mass ratios remain constant after P14

• in addition, adult mutant lenses lack cataracts, indicating normal attainment and maintenance of lens transparency

abnormal eye development ( J:73875 )

• in mutant mice, the postnatal ocular growth rate lags behind that of wild-type littermates

abnormal lens development ( J:73875 )

• in mutant mice, the postnatal lens growth rate lags behind that of wild-type littermates

• however, mutant lenses synthesize markers of lens differentiation at appropriate levels and exhibit normal crystallin solubility

microphthalmia ( J:73875 )

• at P7, mutant eyes are proportionately smaller but show normal anatomy

• by P14, the mutant eye mass is reduced by 25% relative to the wild-type

• however, no significant differences in eye mass are noted at P0, and eye and lens mass ratios remain constant after P14