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Phenotypes Associated with This Genotype
Genotype
MGI:2656252
Allelic
Composition
St8sia1tm1Kfk/St8sia1tm1Kfk
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
St8sia1tm1Kfk mutation (2 available); any St8sia1 mutation (8 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• homozygotes show a general increase in the proliferative response to various stimuli (concanavalin A, anti-CD3) relative to wild-type mice

nervous system
N
• homozygotes exhibit a nearly normal brain size, shape and weight, with no detectable histological alterations in the cortex, striatum, callosum, hippocampus, ventricles, choroid plexus, cerebellum, and brain stem
• no abnormalities in laminar architecture or number of neurons are detected in the retina
• at 10 wks after resection of the hypoglossal nerve, homozygotes show a ~45% reduction in nerve regeneration along with a ~50% decrease in the number of surviving neurons relative to wild-type mice, indicating impaired repair of damaged hypoglossal nerves

immune system
N
• homozygotes exhibit no detectable differences in thymus or spleen size, shape, and cellularity relative to wild-type littermates
• mutant thymocytes display normal sensitivity to Fas-mediated apoptosis induced by Jo2 (1-1,000 ng/ml) in the presence of cycloheximide
• homozygotes show a general increase in the proliferative response to various stimuli (concanavalin A, anti-CD3) relative to wild-type mice

hematopoietic system
• homozygotes show a general increase in the proliferative response to various stimuli (concanavalin A, anti-CD3) relative to wild-type mice

behavior/neurological
N
• homozygotes are behaviorally normal with no signs of ataxia and no significant differences in hindlimb reflex, posture, spontaneous motor activity, swimming ability, and flinch hearing relative to wild-type control mice
• homozygotes exhibit no memory or learning deficits as determined by the Morris water-maze test, passive avoidance test, and Y-maze test


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
08/13/2019
MGI 6.14
The Jackson Laboratory