About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:2656035
Allelic
Composition
Clec3btm1Umw/Clec3btm1Umw
Genetic
Background
involves: 129S1/Sv * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Clec3btm1Umw mutation (0 available); any Clec3b mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
skeleton
N
• at 16 weeks of age, homozygotes exhibit a normal peak bone mass density and are not more susceptible to ovariectomy-induced osteoporosis than control mice, as determined by dual-emission X-ray absorptiometry scanning (J:72638)
• at 16 weeks of age, homozygotes exhibit a normal peak bone mass density and are not more susceptible to ovariectomy-induced osteoporosis than control mice, as determined by dual-emission X-ray absorptiometry scanning (J:72638)
• at 6 months of age, intervertebral disk material is asymmetrical in shape: expanded and loose in structure at the convex side and narrowed and compressed at the concave side (J:72638)
• at 6 months of age, intervertebral disk material is asymmetrical in shape: expanded and loose in structure at the convex side and narrowed and compressed at the concave side (J:72638)
• an asymmetric development of the intervertebral disk is observed at 6 months (J:72638)
• an asymmetric development of the intervertebral disk is observed at 6 months (J:72638)
• starting at 3-6 months of age, homozygotes exhibit an abnormal anteroposterior curvature of the spine (kyphosis) (J:72638)
• at 6 months of age, homozygotes display a mean thoracic angle of 93 2 vs 73C 2 observed in heterozygotes (J:72638)
• at 6 and 12 months of age, spinal curvature is increased due to asymmetric development of the intervertebral disk and asymmetric activity of the growth plates (J:72638)
• however, no apparent muscle pathology is observed (J:72638)
• starting at 3-6 months of age, homozygotes exhibit an abnormal anteroposterior curvature of the spine (kyphosis) (J:72638)
• at 6 months of age, homozygotes display a mean thoracic angle of 93 2 vs 73C 2 observed in heterozygotes (J:72638)
• at 6 and 12 months of age, spinal curvature is increased due to asymmetric development of the intervertebral disk and asymmetric activity of the growth plates (J:72638)
• however, no apparent muscle pathology is observed (J:72638)
• in addition to kyphosis, homozygotes display a cervical lordosis (J:72638)
• however, neither scoliosis nor signs of halisteresis or compression fractures are observed (J:72638)
• in addition to kyphosis, homozygotes display a cervical lordosis (J:72638)
• however, neither scoliosis nor signs of halisteresis or compression fractures are observed (J:72638)
• ~30% of homozygotes display three major pathological changes of the vertebrae, including: (J:72638)
• anterior wedging, i.e., reduction of the anterior height of the corpora due to angulation of the terminal plates, with occasional loss of definition or irregularity of the terminal plates (J:72638)
• rounding or a tip-like look of the vertebrae (J:72638)
• an overall shortening and/or broadening of the vertebrae (J:72638)
• however, no pathological changes of the long bones are observed by X-ray analysis (J:72638)
• ~30% of homozygotes display three major pathological changes of the vertebrae, including: (J:72638)
• anterior wedging, i.e., reduction of the anterior height of the corpora due to angulation of the terminal plates, with occasional loss of definition or irregularity of the terminal plates (J:72638)
• rounding or a tip-like look of the vertebrae (J:72638)
• an overall shortening and/or broadening of the vertebrae (J:72638)
• however, no pathological changes of the long bones are observed by X-ray analysis (J:72638)
• at 6 months of age, increased thoracic curvature is associated with a thickening and broadening of the vertebral bodies (J:72638)
• at 6 months of age, increased thoracic curvature is associated with a thickening and broadening of the vertebral bodies (J:72638)
• an asymmetric activity of the growth plates is observed at 6 months of age (J:72638)
• at 12 months of age, mutant spines display various degrees of irregular growth plates associated with protrusions of vertebral disk material into the cavum subarachnoidale or into the vertebral bodies (J:72638)
• an asymmetric activity of the growth plates is observed at 6 months of age (J:72638)
• at 12 months of age, mutant spines display various degrees of irregular growth plates associated with protrusions of vertebral disk material into the cavum subarachnoidale or into the vertebral bodies (J:72638)

Mouse Models of Human Disease
OMIM ID Ref(s)
Scheuermann Disease 181440 J:72638


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
02/02/2016
MGI 6.02
The Jackson Laboratory