Phenotypes Associated with This Genotype

Genotype
MGI:2655846

• Allelic Composition: St6gal1^tm1Jxm/St6gal1^tm1Jxm
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

peritoneal inflammation ( J:140547 )

• intraperitoneal thioglycollate elicitation recruits double the number of leukocyte cells compared to controls one day after elicitation

decreased transitional stage B cell number ( J:132991 )

• T2 follicular and marginal zone precursors are reduced by 65% and 87%, respectively

increased neutrophil cell number ( J:140547 )

• stimulating the release of neutrophils from the bone marrow by G-CSF administration leads to twice as many neutrophils in circulation as controls

decreased marginal zone B cell number ( J:132991 )

• marginal zone B cell numbers are reduced by about half

abnormal dendritic cell physiology ( J:132991 )

• immature dendritic cells (iDC) are unable to inhibit B cell activation from a distance as wild-type iDC are

digestive/alimentary system

peritoneal inflammation ( J:140547 )

• intraperitoneal thioglycollate elicitation recruits double the number of leukocyte cells compared to controls one day after elicitation

hematopoietic system

decreased transitional stage B cell number ( J:132991 )

• T2 follicular and marginal zone precursors are reduced by 65% and 87%, respectively

increased neutrophil cell number ( J:140547 )

• stimulating the release of neutrophils from the bone marrow by G-CSF administration leads to twice as many neutrophils in circulation as controls

decreased marginal zone B cell number ( J:132991 )

• marginal zone B cell numbers are reduced by about half