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Phenotypes Associated with This Genotype
Genotype
MGI:2655804
Allelic
Composition
Mefvtm1Chae/Mefvtm1Chae
Genetic
Background
either: (involves: 129S6/SvEvTac) or (involves: 129S6/SvEvTac * C57BL/6)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mefvtm1Chae mutation (0 available); any Mefv mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• macrophages exhibit resistance to apoptosis (J:82763)
• macrophages exhibit resistance to apoptosis (J:82763)
• increase in the fever response to LPS injections (J:82763)
• increase in the fever response to LPS injections (J:82763)
• mutants are hypersensitive to endotoxin; within an hour of LPS injection, mutants become more severely hypothermic than controls and mice treated with LPS and/or D-galactosamine, a hepatocyte-sensitizing agent, show increased lethality compared to controls (J:82763)
• mutants are hypersensitive to endotoxin; within an hour of LPS injection, mutants become more severely hypothermic than controls and mice treated with LPS and/or D-galactosamine, a hepatocyte-sensitizing agent, show increased lethality compared to controls (J:82763)

homeostasis/metabolism
• unchallenged mutants have several-hour intervals with body temperatures greater than 39 degrees Celcius more frequently than wild type and fevers that are unpredictable (J:82763)
• unchallenged mutants have several-hour intervals with body temperatures greater than 39 degrees Celcius more frequently than wild type and fevers that are unpredictable (J:82763)

cellular
• macrophages exhibit resistance to apoptosis (J:82763)
• macrophages exhibit resistance to apoptosis (J:82763)

hematopoietic system
• macrophages exhibit resistance to apoptosis (J:82763)
• macrophages exhibit resistance to apoptosis (J:82763)

Mouse Models of Human Disease
OMIM ID Ref(s)
Familial Mediterranean Fever; FMF 249100 J:82763


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory