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Phenotypes Associated with This Genotype
Genotype
MGI:2655588
Allelic
Composition
Tpst1tm1Klm/Tpst1tm1Klm
Genetic
Background
129S-Tpst1tm1Klm
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tpst1tm1Klm mutation (0 available); any Tpst1 mutation (30 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• mean body weight is normal through weaning at 3 weeks of age
• by 5-6 weeks of age weights are approximately 5% less than controls
• homozygotes are otherwise healthy through 12 months of age

reproductive system
• post implantation fetal loss occurs between E8.5 and E15.5 and is 3X higher than controls
• homozygous females produce smaller sized litters regardless of the paternal genotype
• litter size reduction independent of fetal genotype

behavior/neurological
• increased incidence of perinatal mortality
• 28% of pups born die within 48 hours of birth


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory