Phenotypes Associated with This Genotype

Genotype
MGI:2655565

• Allelic Composition: Traf2^tm1Mak/Traf2^tm1Mak
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality throughout fetal growth and development, incomplete penetrance ( J:44360 )

• fewer than expected homozygotes are present at E16.5 (12%) and E17.5 (18.5%)

• however, normal Mendelian ratios are observed until E14.5, in the absence of developmental or morphological defects

perinatal lethality, incomplete penetrance ( J:44360 )

• only 10% of homozygotes are recovered at the time of birth

postnatal lethality, incomplete penetrance ( J:44360 )

• Background Sensitivity: on a mixed genetic background involving only 129 and C57BL/6, only 6% (vs expected 25%) of homozygotes are viable at 3 weeks after birth; the frequency of viable homozygotes is higher on a mixed background involving BALB/c (10%), and reduced on a background that is closer to the inbred B6 strain (3.4%)