Phenotypes for Heph Hfe MGI:2655486 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Heph^sla/Heph^sla Hfe^tm2Nca/Hfe^tm2Nca
Genetic Background	involves: 129S6/SvEvTac * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Heph^sla mutation (1 available); any Heph mutation (11 available)
Hfe^tm2Nca mutation (1 available); any Hfe mutation (35 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

increased intestine iron level ( J:62112 )

• increased iron loading in the mucosa of the proximal duodenum

increased liver iron level ( J:62112 )

• increased hepatic iron loading

• less hepatic iron loading than than the single Hfe^tm2Nca homozygous mutant

digestive/alimentary system

increased intestine iron level ( J:62112 )

• increased iron loading in the mucosa of the proximal duodenum

liver/biliary system

increased liver iron level ( J:62112 )

• increased hepatic iron loading

• less hepatic iron loading than than the single Hfe^tm2Nca homozygous mutant

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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