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Phenotypes Associated with This Genotype
Genotype
MGI:2655485
Allelic
Composition		 Hfetm2Nca/Hfetm2Nca
Slc11a2mk/Slc11a2mk
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6J * MK/ReJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hfetm2Nca mutation (1 available); any Hfe mutation (35 available)
Slc11a2mk mutation (2 available); any Slc11a2 mutation (36 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality ( J:62112 )
• some mice die prior to weaning
• increased viability relative to Slc11a2mk homozygous mutant mice

homeostasis/metabolism
decreased liver iron level ( J:62112 )
• hepatic iron levels similar to those observed in Slc11a2mk homozygous mutant mice

liver/biliary system
decreased liver iron level ( J:62112 )
• hepatic iron levels similar to those observed in Slc11a2mk homozygous mutant mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory