Phenotypes for Hfe Slc11a2 MGI:2655485 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Hfe^tm2Nca/Hfe^tm2Nca Slc11a2^mk/Slc11a2^mk
Genetic Background	involves: 129S6/SvEvTac * C57BL/6J * MK/ReJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hfe^tm2Nca mutation (1 available); any Hfe mutation (35 available)
Slc11a2^mk mutation (2 available); any Slc11a2 mutation (36 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality ( J:62112 )

• some mice die prior to weaning

• increased viability relative to Slc11a2^mk homozygous mutant mice

homeostasis/metabolism

decreased liver iron level ( J:62112 )

• hepatic iron levels similar to those observed in Slc11a2^mk homozygous mutant mice

liver/biliary system

decreased liver iron level ( J:62112 )

• hepatic iron levels similar to those observed in Slc11a2^mk homozygous mutant mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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