Analysis Tools
mortality/aging
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• Background Sensitivity: F2, F3, and F4 generation males obtained by crossing F1, F2 or F3 heterozygous females to C57BL/6 males die between P7 and P21. However 50% of males obtained from F1 or F2 heterozygous females crossed to chimeric males or to 129P2/OlaHsd males survive to adulthood
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behavior/neurological
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• suck poorly and have less milk in their stomachs than controls
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• excessive agitation when handled, loss of bladder control
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limb grasping
(
J:33951
)
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• when lifted by tails, mutants draw their limbs in toward their bodies instead of extending their limbs
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• a continuous tremor is seen in F2, F3, and F4 generation males that were obtained by crossing F1, F2 or F3 heterozygous females to C57BL/6 males
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• F2, F3, and F4 generation males, obtained by crossing F1, F2 or F3 heterozygous females to C57BL/6 males, have difficulty maintaining an upright position
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• seen in F2, F3, and F4 generation males obtained by crossing F1, F2 or F3 heterozygous females to C57BL/6 males
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• limbs are held in an abnormal positions
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digestive/alimentary system
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• Background Sensitivity: 100% penetration of distended colon, primarily affecting the cecum and the proximal end of the colon, in F2, F3, and F4 generation males obtained from crosses of F1, F2, or F3 heterozygous females with C57BL/6 males but not observed in mice from F1 or F2 heterozygous matings to chimeric males or 129P2/OlaHsd males
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• narrow rectum
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growth/size/body
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• by 2-3 days of age, males are smaller and appear wasted
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• body weight at P5 is 50% that of wild-type
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immune system
small thymus
(
J:33951
)
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• 10% smaller thymus compared to wild-type
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muscle
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• muscle rigidity
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hematopoietic system
small thymus
(
J:33951
)
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• 10% smaller thymus compared to wild-type
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endocrine/exocrine glands
small thymus
(
J:33951
)
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• 10% smaller thymus compared to wild-type
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