Analysis Tools
mortality/aging
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• Background Sensitivity: females on a predominantly C57BL/6 background die between P7 and P21 while females maintained on a more 129P2/OlaHsd background show 50% survival to adulthood
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behavior/neurological
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• suck poorly and have less milk in their stomachs than controls
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• excessive agitation during handling, loss of bladder control
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limb grasping
(
J:33951
)
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• when lifted by tails, mutants draw their limbs in toward their bodies instead of extending their limbs
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• females predominantly on a C57BL/6 background (F2-F4) have difficulty maintaining an upright position
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• seen in females on the predominantly C57BL/6 background
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• limbs held in an abnormal posture
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digestive/alimentary system
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• Background Sensitivity: 100% penetration of distended colon, primarily affecting the cecum and the proximal end of the colon, in females on a predominantly C57BL/6 background but is not observed in females on a more 129P2/OlaHsd background
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• narrow rectum
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growth/size/body
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• smaller by 2-3 days of age
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• weigh less at P5
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immune system
small thymus
(
J:33951
)
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• thymus is reduced in size, 10% of the size of wild-type
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muscle
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• muscle rigidity
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hematopoietic system
small thymus
(
J:33951
)
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• thymus is reduced in size, 10% of the size of wild-type
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endocrine/exocrine glands
small thymus
(
J:33951
)
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• thymus is reduced in size, 10% of the size of wild-type
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