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Phenotypes Associated with This Genotype
Genotype
MGI:2655442
Allelic
Composition		 Aqp3tm1Ask/Aqp3tm1Ask
Aqp4tm1Ask/Aqp4tm1Ask
Genetic
Background		 involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aqp3tm1Ask mutation (0 available); any Aqp3 mutation (26 available)
Aqp4tm1Ask mutation (0 available); any Aqp4 mutation (46 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
renal/urinary system
decreased urine osmolality ( J:61675 )
• urine osmolality is decreased when given free access to water and the increase in osmolality induced by 36 hour water deprivation or 1-desamino-8-D-arginine-vasopressin treatment is less than that in Aqp3 single homozygotes

homeostasis/metabolism
decreased urine osmolality ( J:61675 )
• urine osmolality is decreased when given free access to water and the increase in osmolality induced by 36 hour water deprivation or 1-desamino-8-D-arginine-vasopressin treatment is less than that in Aqp3 single homozygotes

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory