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Phenotypes Associated with This Genotype
Genotype
MGI:2654949
Allelic
Composition
Nodaltm1Hmd/Nodal+
Tg(Rr443-Lefty1,-lacZ)36Hmd/0
Genetic
Background
either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6N) or (involves: 129S1/Sv * 129T2/SvEms * 129X1/SvJ)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nodaltm1Hmd mutation (1 available); any Nodal mutation (41 available)
Tg(Rr443-Lefty1,-lacZ)36Hmd mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• positions of the great arteries are disorganized
• both atria of heart resembles the right atrium
• the apex of the heart is oriented to the right

growth/size/body
• right isomerism of the heart and lungs
• both atria of heart resembles the right atrium
• 1/3 mice exhibit three lobes in the left lung and four lobes in the right lung, while the other 2/3 mice show typical right isomerism of the lung

embryo
• left-right isomerism of some internal organs

hematopoietic system
• spleen is positioned normally but is smaller in size

respiratory system
• 1/3 mice exhibit three lobes in the left lung and four lobes in the right lung, while the other 2/3 mice show typical right isomerism of the lung

digestive/alimentary system
• gut looping is incomplete

liver/biliary system
• clefts in the medial lobes of the liver

immune system
• spleen is positioned normally but is smaller in size


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
01/20/2026
MGI 6.24
The Jackson Laboratory