Phenotypes Associated with This Genotype

Genotype
MGI:2654944

• Allelic Composition: Nodal^tm1Hmd/Nodal^tm1Hmd
• Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6N) or (involves: 129S1/Sv * 129T2/SvEms * 129X1/SvJ)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:82703 )

• 75% of embryos survive until birth but die immediately at or within a few hours after birth

embryonic lethality during organogenesis, incomplete penetrance ( J:82703 )

• 25% of embryos are arrested at midgestation, around E13, while the rest develop to term

growth/size/body

right-sided isomerism ( J:82703 )

• right isomerism of the heart and lungs

right atrial isomerism ( J:82703 )

• both atria of heart resembles the right atrium

right pulmonary isomerism ( J:82703 )

• both the left and right lungs of mutants have four lobes

cardiovascular system

transposition of great arteries ( J:82703 )

• reversed position of the great arteries

abnormal heart position or orientation ( J:82703 )

• random orientation of the heart apex to the left, right, or middle

right atrial isomerism ( J:82703 )

• both atria of heart resembles the right atrium

embryo

abnormal left-right axis patterning ( J:82703 )

• internal organs exhibit right-sided isomerism

embryonic growth arrest ( J:82703 )

• approximately 25% of homozygotes arrest at midgestation, around E13

hematopoietic system

abnormal spleen morphology ( J:82703 )

• mutants exhibit several punctate spleens or one small spleen

spleen hypoplasia ( J:82703 )

immune system

abnormal spleen morphology ( J:82703 )

• mutants exhibit several punctate spleens or one small spleen

spleen hypoplasia ( J:82703 )

liver/biliary system

abnormal liver morphology ( J:82703 )

• abnormal liver lobation, including clefts in the medial lobes

respiratory system

right pulmonary isomerism ( J:82703 )

• both the left and right lungs of mutants have four lobes

digestive/alimentary system

abnormal stomach position or orientation ( J:82703 )

• random rotation of the stomach

abnormal digestive system development ( J:82703 )

• disorganization of gut coiling