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Phenotypes Associated with This Genotype
Genotype
MGI:2654920
Allelic
Composition		 Plcb4tm1Tyo/Plcb4tm1Tyo
Genetic
Background		 involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plcb4tm1Tyo mutation (0 available); any Plcb4 mutation (131 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal nervous system physiology ( J:72939 )
• the metabotropic glutamate receptor 1-mediated calcium response is reduced in the rostral cerebellum
reduced long-term depression ( J:72939 )
• Purkinje cells exhibit reduced long term depression (LTD) after a conjunctive stimulation protocol in the rostral cerebellum, whereas LTD is intact in caudal cerebellum

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
06/16/2026
MGI 6.24 		The Jackson Laboratory