Phenotypes Associated with This Genotype

Genotype
MGI:2654891

• Allelic Composition: Tub^tub/Tub^tub; Tulp1^tm1Pjn/Tulp1^tm1Pjn
• Genetic Background: involves: 129X1/SvJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

short photoreceptor inner segment ( J:70710 )

• at P14, the double mutant inner segments are extremely short

absent photoreceptor outer segment ( J:70710 )

• at P14, the double outer segments are absent

retina photoreceptor degeneration ( J:70710 )

• although all retinal layers are normally present at P14, double mutant photoreceptors undergo rapid degeneration by P17, such that the photoreceptor layer is reduced to a single row of nuclei

• this rate of decline is much faster than in either single homozygote alone, where early stages of photoreceptor layer degeneration are observed at P20

nervous system

short photoreceptor inner segment ( J:70710 )

• at P14, the double mutant inner segments are extremely short

absent photoreceptor outer segment ( J:70710 )

• at P14, the double outer segments are absent

retina photoreceptor degeneration ( J:70710 )

• although all retinal layers are normally present at P14, double mutant photoreceptors undergo rapid degeneration by P17, such that the photoreceptor layer is reduced to a single row of nuclei

• this rate of decline is much faster than in either single homozygote alone, where early stages of photoreceptor layer degeneration are observed at P20