Analysis Tools
mortality/aging
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• affected heterozygous mutant embryos exhibit embryonic lethality with excessive neuroepithelial apoptosis in the hindbrain
• however, no overt abnormalities are detected in live-born heterozygous mutant mice
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nervous system
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• at E10.5, affected heterozygous mutant embryos display excessive apoptosis of neuroepithelial cells in the hindbrain region
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• at E10.5, a few heterozygotes exhibit an open neural tube
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• at E10.5, 18% of heterozygous mutant embryos display an abnormal brain phenotype that is less severe than that observed in homozygous mutant embryos
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• at E10.5, the majority of affected heterozygous mutant embryos display abnormal fore-, mid- and hindbrain development
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• at E10.5, affected heterozygotes exhibit an underdeveloped and disorganized midbrain
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• at E10.5, affected heterozygotes exhibit an underdeveloped and disorganized forebrain
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• at E10.5, affected heterozygotes exhibit an underdeveloped and disorganized hindbrain with a collapsed roof
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cardiovascular system
hemorrhage
(
J:70060
)
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• some heterozygous mutant embryos display sites of hemorrhage at E12.5 and blood loss at E14.5
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embryo
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• at E10.5, a few heterozygotes exhibit an open neural tube
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cellular
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• at E10.5, affected heterozygous mutant embryos display excessive apoptosis of neuroepithelial cells in the hindbrain region
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