Phenotypes Associated with This Genotype

Genotype
MGI:2654876

• Allelic Composition: Zeb1^Tw/Zeb1^Tw
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal olfactory sensory neuron morphology ( J:73312 )

• the olfactory receptor neuron in the epithelium is less differentiated at E16.5 and at birth than in wild-type mice, and remains rounded in shape and euchromatic

• at E14.5, many mature olfactory receptor neurons are randomly found all over the mesenchyme

abnormal olfactory bulb morphology ( J:73312 )

• abnormally shaped olfactory bulb in newborn pups; instead of ending in a triangular cone at the rostral end of the cerebellar lobes, one or sometimes both bulbs extend into elongated tips

• the olfactory bulb often protrudes into the nasal cavity through the ethmoid bone

abnormal olfactory bulb layer morphology ( J:73312 )

• the distinct layers of the olfactory bulb are not apparent in mutants

abnormal olfactory bulb glomerular layer morphology ( J:73312 )

• the glomerular layer is virtually nonexistant

abnormal olfactory bulb mitral cell layer morphology ( J:73312 )

• mitral cells are scattered over the entire surface of the olfactory bulb

abnormal olfactory neuron innervation pattern ( J:73312 )

• olfactory innervation is altered with reduced number of connections in the olfactory bulb

abnormal olfactory nerve morphology ( J:73312 )

• the olfactory nerves are not organized into distinct tracts, instead, they are loosely packed and scattered in the mesenchyme of the nasal cavity or present as clumps of fibers

• very few olfactory nerves reach the olfactory bulb

respiratory system

abnormal turbinate morphology ( J:73312 )

• the superior, middle, and inferior turbinates are not clearly defined

• present as masses of tissues

abnormal nasal cavity morphology ( J:73312 )

• severe alterations in the morphology of the nasal cavity

abnormal nasal septum morphology ( J:73312 )

• the nasal septum appears more bulbous

abnormal olfactory epithelium morphology ( J:73312 )

• the olfactory epithelium is thinner at E14.5 and at birth

abnormal olfactory sensory neuron morphology ( J:73312 )

• the olfactory receptor neuron in the epithelium is less differentiated at E16.5 and at birth than in wild-type mice, and remains rounded in shape and euchromatic

• at E14.5, many mature olfactory receptor neurons are randomly found all over the mesenchyme

craniofacial

abnormal ethmoid bone morphology ( J:73312 )

• protrusion of the olfactory bulb into the nasal cavity through the ethmoid bone is accompanied by breakage of the cribriform plate

abnormal cribriform plate morphology ( J:73312 )

• breakage of the cribriform plate

abnormal turbinate morphology ( J:73312 )

• the superior, middle, and inferior turbinates are not clearly defined

• present as masses of tissues

unilateral cleft upper lip ( J:73312 )

• unilateral cleft of the lip

cleft secondary palate ( J:73312 )

• observed in all mutants

abnormal nasal cavity morphology ( J:73312 )

• severe alterations in the morphology of the nasal cavity

abnormal nasal septum morphology ( J:73312 )

• the nasal septum appears more bulbous

abnormal olfactory epithelium morphology ( J:73312 )

• the olfactory epithelium is thinner at E14.5 and at birth

abnormal olfactory sensory neuron morphology ( J:73312 )

• the olfactory receptor neuron in the epithelium is less differentiated at E16.5 and at birth than in wild-type mice, and remains rounded in shape and euchromatic

• at E14.5, many mature olfactory receptor neurons are randomly found all over the mesenchyme

skeleton

abnormal ethmoid bone morphology ( J:73312 )

• protrusion of the olfactory bulb into the nasal cavity through the ethmoid bone is accompanied by breakage of the cribriform plate

abnormal cribriform plate morphology ( J:73312 )

• breakage of the cribriform plate

abnormal turbinate morphology ( J:73312 )

• the superior, middle, and inferior turbinates are not clearly defined

• present as masses of tissues

taste/olfaction

abnormal olfactory epithelium morphology ( J:73312 )

• the olfactory epithelium is thinner at E14.5 and at birth

abnormal olfactory sensory neuron morphology ( J:73312 )

• the olfactory receptor neuron in the epithelium is less differentiated at E16.5 and at birth than in wild-type mice, and remains rounded in shape and euchromatic

• at E14.5, many mature olfactory receptor neurons are randomly found all over the mesenchyme

digestive/alimentary system

cleft secondary palate ( J:73312 )

• observed in all mutants

growth/size/body

abnormal turbinate morphology ( J:73312 )

• the superior, middle, and inferior turbinates are not clearly defined

• present as masses of tissues

unilateral cleft upper lip ( J:73312 )

• unilateral cleft of the lip

cleft secondary palate ( J:73312 )

• observed in all mutants

abnormal nasal cavity morphology ( J:73312 )

• severe alterations in the morphology of the nasal cavity

abnormal nasal septum morphology ( J:73312 )

• the nasal septum appears more bulbous

abnormal olfactory epithelium morphology ( J:73312 )

• the olfactory epithelium is thinner at E14.5 and at birth

abnormal olfactory sensory neuron morphology ( J:73312 )

• the olfactory receptor neuron in the epithelium is less differentiated at E16.5 and at birth than in wild-type mice, and remains rounded in shape and euchromatic

• at E14.5, many mature olfactory receptor neurons are randomly found all over the mesenchyme