Phenotypes Associated with This Genotype

Genotype
MGI:2654860

• Allelic Composition: \Zeb1^Tw/\Zeb1⁺
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

hyperactivity ( J:60496 )

• heterozygotes display hyperactivity, twirling around the cage in periodic spurts

bidirectional circling ( J:60496 )

• heterozygotes exhibit bidirectional "twirling" or circling behavior

growth/size/body

increased susceptibility to age related obesity ( J:60496 )

• most male and female heterozygotes become obese as they reach maturity

• onset of obesity varies from 2 months to 3 months of age in some heterozygotes

decreased body size ( J:60496 )

• young heterozygotes remain smaller than wild-type, despite normal feeding

reproductive system

transmission ratio distortion ( J:60496 )

• a less than 1:1 ratio of heterozygous (43.6%) to wild-type (56.4%) pups is obtained from matings of heterozygous males with wild-type females, suggesting increased lethality either in utero or prior to genotyping at 10 days after birth

female infertility ( J:60496 )

♀ • obese female heterozygotes tend to become sterile

reduced male fertility ( J:60496 )

♂ • obese male heterozygotes breed at a reduced rate

hearing/vestibular/ear

abnormal inner ear morphology ( J:60496 )

• heterozygotes display inner ear defects (not shown)

pigmentation

diluted coat color ( J:60496 )

• most heterozygotes display a lighter coat color than wild-type mice

integument

diluted coat color ( J:60496 )

• most heterozygotes display a lighter coat color than wild-type mice

sparse hair ( J:60496 )

• most heterozygotes have sparse hair