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Phenotypes Associated with This Genotype
Genotype
MGI:2654784
Allelic
Composition
Mertktm1Grl/Mertktm1Grl
Tyro3tm1Grl/Tyro3tm1Grl
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mertktm1Grl mutation (2 available); any Mertk mutation (66 available)
Tyro3tm1Grl mutation (1 available); any Tyro3 mutation (40 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands

reproductive system
• 3.7% of females exhibit vaginal atresia
• reduced amount of mature sperm in the epididymis
• double mutant Sertoli cells show a ~35% decrease in phagocytosis of apoptotic spermatogenic cells relative to wild-type controls, as determined by lipid droplet formation using Oil Red O staining; this reduction is similar to that observed in Mertktm1Grl singly mutant Sertoli cells

cellular
• reduced amount of mature sperm in the epididymis


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/18/2025
MGI 6.24
The Jackson Laboratory