Analysis Tools
reproductive system
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• mutant Sertoli cells show a 35% decrease in phagocytosis of apoptotic spermatogenic cells relative to wild-type controls, as determined by lipid droplet formation using Oil Red O staining
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vision/eye
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• outer segment tips of the retina are aberrantly extended into the RPE cell layer at P17 such that by P21, there is a 33% increase in overall outer segment length relative to wild-type
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• by P35, the outer segment layer becomes very disordered compared to wild-type
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• by 2 months of age, nearly all photoreceptors die by apoptosis
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• retinal pigment epithelial cells are unable to phagocytose the distal ends of the photoreceptor outer segments
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nervous system
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• outer segment tips of the retina are aberrantly extended into the RPE cell layer at P17 such that by P21, there is a 33% increase in overall outer segment length relative to wild-type
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• by P35, the outer segment layer becomes very disordered compared to wild-type
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• by 2 months of age, nearly all photoreceptors die by apoptosis
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hematopoietic system
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• 2-fold increase in spleen size
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cardiovascular system
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• mice exhibit normal vascular permeability in the liver
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immune system
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• 2-fold increase in spleen size
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pigmentation
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• retinal pigment epithelial cells are unable to phagocytose the distal ends of the photoreceptor outer segments
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growth/size/body
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• 2-fold increase in spleen size
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