Phenotypes Associated with This Genotype

Genotype
MGI:2654726

• Allelic Composition: Crip3^tm1Mjb/Crip3^tm1Mjb
• Genetic Background: either: (involves: 129S/Sv) or (involves: 129S/Sv * C57BL/6)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

small thymus ( J:72942 )

• homozygotes display a significant reduction in thymus size relative to wild-type or heterozygous control littermates

thymus hypoplasia ( J:72942 )

• at 3 to 26 weeks of age, homozygotes display a ~30% reduction in thymocyte cellularity, with a proportional decrease in each thymocyte subpopulation

• however, thymocyte development and thymus architecture appear to be normal, and no differences are observed in T-cell selection or splenocyte number relative to sex- and age-matched wild-type littermates

decreased thymocyte number ( J:72942 )

• on average, homozygotes exhibit ~30% fewer thymocytes than wild-type control littermates

• however, the percentages of each thymocyte subpopulation (CD4SP, CD8SP, DP, and DN) are comparable to those of control littermates

immune system

small thymus ( J:72942 )

• homozygotes display a significant reduction in thymus size relative to wild-type or heterozygous control littermates

thymus hypoplasia ( J:72942 )

• at 3 to 26 weeks of age, homozygotes display a ~30% reduction in thymocyte cellularity, with a proportional decrease in each thymocyte subpopulation

• however, thymocyte development and thymus architecture appear to be normal, and no differences are observed in T-cell selection or splenocyte number relative to sex- and age-matched wild-type littermates

decreased thymocyte number ( J:72942 )

• on average, homozygotes exhibit ~30% fewer thymocytes than wild-type control littermates

• however, the percentages of each thymocyte subpopulation (CD4SP, CD8SP, DP, and DN) are comparable to those of control littermates

endocrine/exocrine glands

small thymus ( J:72942 )

• homozygotes display a significant reduction in thymus size relative to wild-type or heterozygous control littermates

thymus hypoplasia ( J:72942 )

• at 3 to 26 weeks of age, homozygotes display a ~30% reduction in thymocyte cellularity, with a proportional decrease in each thymocyte subpopulation

• however, thymocyte development and thymus architecture appear to be normal, and no differences are observed in T-cell selection or splenocyte number relative to sex- and age-matched wild-type littermates

decreased thymocyte number ( J:72942 )

• on average, homozygotes exhibit ~30% fewer thymocytes than wild-type control littermates

• however, the percentages of each thymocyte subpopulation (CD4SP, CD8SP, DP, and DN) are comparable to those of control littermates