Phenotypes Associated with This Genotype

Genotype
MGI:2654710

• Allelic Composition: Hmga2^tm1Cha/Hmga2^tm1Cha
• Genetic Background: involves: 129S7/SvEvBrd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

azoospermia ( J:126188 )

♂ • mice lack spermatozoa

abnormal spermatogonia morphology ( J:126188 )

♂ • spermatogonia exhibit signs of cellular damage unlike in wild-type mice

male infertility ( J:126188 )

♂

growth/size/body

shortened head ( J:28571 )

decreased birth weight ( J:28571 )

• low birth weight

decreased body weight ( J:28571 , J:61493 )

• adult mice weight 40% of wild-type (J:28571)

• 47% of wild-type (J:61493)

decreased susceptibility to diet-induced obesity ( J:61493 )

craniofacial

shortened head ( J:28571 )

homeostasis/metabolism

decreased susceptibility to diet-induced obesity ( J:61493 )

cellular

azoospermia ( J:126188 )

♂ • mice lack spermatozoa

abnormal spermatogonia morphology ( J:126188 )

♂ • spermatogonia exhibit signs of cellular damage unlike in wild-type mice