Phenotypes Associated with This Genotype

Genotype
MGI:2654631

• Allelic Composition: Nfia^tm1Rmg/Nfia^tm1Rmg
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Spectrum of kidney histology in Nfia^tm1Rmg/Nfia^tm1Rmg newborns

nervous system

syringomyelia ( J:122749 )

• 66% of newborns exhibit syringomyelia that is manifested as an enlarged central canal and confined to the lumbar region

renal/urinary system

abnormal kidney morphology ( J:122749 )

• 68% of newborns display agenesis, dysplastic, cystic, or duplex kidneys

kidney cyst ( J:122749 )

• in some newborns

hydronephrosis ( J:122749 )

• two mice that survive to P16 develop severe hydronephrosis

dilated renal tubule ( J:122749 )

absent kidney ( J:122749 )

• some newborns exhibit bilateral renal agenesis

duplex kidney ( J:122749 )

• in some newborns

dilated ureter ( J:122749 )

• newborns exhibit duplication and dilatation of the ureter at the ureteropelvic junction

double ureter ( J:122749 )

• newborns exhibit duplication and dilatation of the ureter at the ureteropelvic junction

growth/size/body

kidney cyst ( J:122749 )

• in some newborns